Acylation of Grignard reagents mediated by N-methylpyrrolidone: a remarkable selectivity for the synthesis of ketones.
نویسندگان
چکیده
An efficient user-friendly method of acylation of Grignard reagents to selectively synthesize ketones is presented, which is assisted by simple amides such as NMP, or DMF. The present chemoselective method tolerates a variety of functional groups such as ketone, ester, nitrile and other functional groups.
منابع مشابه
Addition of grignard reagents to aryl acid chlorides: an efficient synthesis of aryl ketones.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 9 15 شماره
صفحات -
تاریخ انتشار 2011